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There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)
79 Because aging is characterized by gradual dysregulation of cellular homeostasis and increased oxidative stress, it is hypothesized that enhanced cAMP signaling could support cellular plasticity and resilience, potentially mitigating certain age-related dysfunctions
Some groups may need a different approach or close supervision, especially those taking other diabetes medicines or those with kidney or liver problems
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