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A proportion of infants and children with sepsis progress to cardiac failure as part of multiple system organ failure (hepatic, renal, cardiac, pulmonary) [100]
10.1038/ncomms12808 181
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Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30
Each tells a different part of the story, and understanding where they agree and disagree is critical for assessing actual risk
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