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Published data from the Dalmasso laboratory shows that MC1R activation by KPV in colonic epithelial cells produces measurable reductions in NF-B nuclear translocation within hours of exposure

These sound alarming, but they are almost always transient and mild

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The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]