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Ice crystal formation denatures the peptide irreversibly Unreconstituted powder (lyophilized): - Store in the freezer at minus 20 degrees Celsius for maximum shelf life (months to years) - Refrigerated storage at 2 to 8 degrees Celsius is acceptable for several months - Room temperature tolerance: 2 to 4 weeks without significant degradation - Keep the desiccant packet in the container to absorb moisture Practical storage tips: - Store vials on a middle shelf of the refrigerator, not in the door

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The addition of B12 to compounded semaglutide is a clinical practice decision rather than an evidence-based protocol with its own trial data