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In preclinical models this raises intracellular NAD and SAM, lowers 1-methylnicotinamide, and suppresses fat-cell lipogenesis, which is the proposed basis for the weight and adiposity reductions seen in obese mice
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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation [3]
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