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The pathogenic side of LL-37 in lupus In lupus patients, LL-37 has been found to form complexes with self-DNA released from dying cells
It is used in laboratory settings to reconstitute peptides and other research compounds
Mouse neurons are more susceptible to ferroptosis due to their dependence on GPX4 and their more developed iron- and lipid-peroxidation-related processes
In type 2 diabetes and related states, this switch is broken: glucagon stays inappropriately high after meals, and the liver keeps producing glucose it does not need, worsening the postprandial spike
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