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In the ATTAIN-2 trial (participants with obesity and type 2 diabetes), GI adverse event rates were somewhat higher than in ATTAIN-1: nausea 20.1-36.4% versus 8.4% with placebo, vomiting 12.8-23.1% versus 3.8%, diarrhea 21.3-27.4% versus 15.0%, and constipation 17.7-22.4% versus 7.8%
Although a standard random-effects model was employed to account for between-study variability, alternative methodological approaches could have further enhanced the robustness of this analysis
Both can cause headaches
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annual kidney function assessment (serum creatinine, estimated glomerular filtration rate, urine albumin-to-creatinine ratio)more frequent if you have existing kidney disease
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