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Figure 4 Due to the influence of renal clearance and dipeptidyl peptidase-4 (DPP-4), GLP-1 has a short natural half-life in the human body, about 12 min (113)
By marrying insulinotropic activities of GLP-1 and E2, we envisioned a synergism on islet -cells that express both ER and GLP-1 receptors (GLP-1R), while improving the therapeutic index of estrogen
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