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Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]
10.2174/157339706776876017 Ekmekcioglu C, Strauss-Blasche G, Holzer F, Marktl W: Effect of sulfur baths on antioxidative defense systems, peroxide concentrations and lipid levels in patients with degenerative osteoarthritis
More than 10 million people in the United States have AMD
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