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Glucagon-like peptide-1 receptor agonists as potential preventive and therapeutic agents in ischemic stroke 1 Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 2 Department of Surgery, Division of Anatomy, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada 3 Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada 4 Banting and Best Diabetes Centre, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Advanced Neurology 2026 , 5(2), 025150027 Received: 7 April 2025 | Revised: 13 July 2025 | Accepted: 22 July 2025 | Published online: 11 September 2025 Stroke remains a significant contributor to mortality and morbidity worldwide, imposing a significant socioeconomic burden and underscoring the urgent need for both preventative and therapeutic strategies