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The World Anti-Doping Agency (WADA) includes it under the category of S0 Non-approved Substances, which covers any pharmacological agent that has not been approved for human use by a regulatory authority

As endogenous GLP-1 has a very short half-life, these central actions are likely to be more relevant during therapeutic use of DPP4-resistant GLP-1R analogs, or in post-gastric bypass surgeries, in which GLP-1 equivalent levels, or postprandial GLP-1, respectively, are augmented and sufficient to elicit anorectic responses at these CNS targets

Adverse event reports Between February 2019 and December 2023, the FDA received 352 adverse event reports related to compounded GLP-1 drugs