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Furthermore, the fact that tracer retention in cortical regions increased with clinical disease severity, as estimated by the Revised ALS Functioning Rating Scale (ALSFRS-R), suggested that OS may be an important factor associated with the development of neurodegeneration in ALS patients [107]
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Useful for Receptor Binding and Signal Transduction Studies Because of its strong and sustained interaction with the IGF-1 receptor, IGF-1 LR3 is widely used to study receptor activation dynamics, downstream signaling cascades, and feedback regulation in controlled experimental environments
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