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This syndrome can indicate a mitochondrial toxicity caused by HIV infection and the antiretroviral medications used to treat it, which in turn can lead to a lack of carnitine, which affects mitochondrial fat metabolism
In animal models, high-dose ketamine (100 mg/kg daily) caused mitochondrial swelling, DNA damage, and ATP production deficits (Huang et al., 2024)
There is also a risk of pancreatitis, and people are advised to seek immediate care if they experience severe abdominal pain
At one year, patients with PCOS on GLP-1s experienced significantly greater weight loss than those on metformin
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