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The former establish methylation patterns on unmethylated DNA [44] and the latter preserves existing methylation patterns by methylating hemi-methylated DNA [46]
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The lack of immunogenicity has practical implications: the peptide can be used for extended periods without loss of efficacy due to antibody neutralization, there is minimal risk of allergic or hypersensitivity reactions, and repeated treatment cycles are supported as prior exposure does not sensitize the immune system
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