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It first drew research interest for its ability to heal stomach ulcers and inflammatory bowel conditions, then expanded to tendon, ligament, muscle, and even bone healing across dozens of preclinical studies (Sikiric et al., PubMed)
Pekkarinen SS, Heinonen IM, Hopia AI
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The first mammalian core clock gene, CLOCK, was identified through studies of mice with abnormal circadian behavior ( Drosophila cycleto form the core CLOCK:BMAL1 complex ( In mammals, as PER and CRY proteins accumulate, they dimerize, enter the nucleus, and inhibit CLOCK:BMAL1 activity, forming the negative feedback loop that is central to circadian timekeeping ( Drosophila , mammalian CRY proteins (CRY1 and CRY2) do not function as photoreceptors
