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For example, patients with conditions like pernicious anemia or significant absorption issuessuch as those caused by gastrointestinal disorders (like Crohns disease or celiac disease), a history of gastric surgery, or certain long-term medicationsoften require higher or more frequent doses, especially when starting treatment
The speed at which B12 treats nerve symptoms shows differences between patients
These investigations have examined the compound's biochemical effects in cultured cells and animal models as part of broader research into NNMT and cellular metabolism Importantly, these findings relate to preclinical research and should not be interpreted as evidence of established clinical efficacy, safety or therapeutic benefit in humans
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