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Rigorous integration therefore requires method selection aligned with study structure, transparent handling of batch effects and missingness mechanisms, and validation strategies anchored to patient-relevant outcomes rather than intermediate surrogates
By inhibiting P-gp, these agents enhance cellular drug retention but may inadvertently increase systemic drug concentrations, posing toxicity risks for narrow-therapeutic-index medications (e.g., chemotherapeutics, cardiovascular drugs) (32, 8890)
Key regulators of ferroptosis The intricate process of ferroptosis involves numerous genes and transcription factors, with a central role attributed to nuclear factor erythroid2-related factor 2 (Nrf2), drawing significant attention
Melanotic neuroectodermal tumor of infancy in the femur: a case report and review of the literature
