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A proven strategy to counteract this is the incorporation of hydrophilic groups within the linker
Alzheimers Dement 21:e70448
Funding This study was supported by the National S&T Major Project of China (2018ZX10301201-008), Natural Science Foundation of China (81702757, 81702346, 81702927, and 81600506), National Key Research and Development Program of China (2018YFC2000500), China Postdoctoral Science Foundation (2017M610463 and 2018M632814)
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