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First, it increases insulin secretion when glucose is high
Stimulation at these sites is generally low at therapeutic ipamorelin doses, but patients with portal hypertension and altered gut physiology may experience more pronounced ghrelin-pathway effects, including appetite stimulation and gastric motility changes
This is why Mounjaro doesn't just "wear off" overnight
For patients with relative contraindications to semaglutide, this test may show that tirzepatide or microdose protocols offer safer, more personalized alternatives
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