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Within experimental models, these compounds are commonly investigated for their interaction with peptide-mediated signalling networks and molecular mechanisms
Canadian Journal of Diabetes , 43 (2), 136145
The pivotal evidence for tirzepatide comes from the SURMOUNT program for weight management ( The New England Journal of Medicine , 2022) and SURMOUNT-OSA for obstructive sleep apnea (NEJM 2024), while the semaglutide STEP trials (NEJM 2021) anchor the single-agonist side
