doi: 10.1158/1541-7786.MCR-16-0003 126 PleasanceEDCheethamRKStephensPJMcBrideDJHumphraySJGreenmanCDet al
The healing peptides guide discusses how different regenerative compounds interact
In addition, the transcriptomic study revealed the activation of abscisic acid, auxin, jasmonic acid biosynthesis and signaling genes during GSH treatment (Cheng et al
GAA is an aldosterone-type triterpenoid derived from Ganoderma lucidum, known for its antioxidant, anti-inflammatory, antidepressant, and anticancer properties ( In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury