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The honest research caveat is that "theoretically additive" is not "experimentally additive" and a researcher who needs to claim synergy must run the combination versus the components in their own model
I can't recall seeing it listed as a side effect of B12
(2) Abid MSR, Qiu H, Tripp BA, de Lima Leite A, Roth HE, Adamec J, Powers R, Checco JW
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