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As per the UK SmPC, treatment begins with 0.25 mg once weekly for 4 weeks (an initiation dose to improve gastrointestinal tolerability), then increases to 0.5 mg once weekly

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In a study of more than 240,000 people, heavier individuals were significantly more likely to form stones than lean ones.[3] The reason is biochemical: obesity and insulin resistance push the kidney to excrete more calcium, oxalate, and uric acid, and they make the urine more acidic close to a perfect recipe for stone crystals