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Adam, J

[1,2] It appears to be potentially more influential on cellular activities than rhIGF-1 due to an apparent significant improvement in its biological activity

Nature 2009

In contrast to melanomas, which acquire additional driver mutations, nevi usually enter a suppressive state of replicative senescence which is regulated by the tumor suppressor gene CDKN2A via its proteins, p14 and p16, and various transcriptional controls of the cell cycle (30, 31)