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As the competition for powerful weight loss efficacy intensifies, Roche has put forward a combination strategy using an amylin analogue to address the most significant weakness of glucagon-like peptide-1 (GLP-1) class therapies: nausea as a side effect

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Document clinical contraindication to semaglutide: Persistent nausea or vomiting preventing dose escalation beyond initial doses, a documented thyroid concern (e.g., personal or family history of MEN 2 or medullary thyroid carcinoma), or another clinically documented intolerance can serve as the basis for the exception request

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