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The subsequent phase 3 trial of tirzepatide demonstrated more effective reductions in the glycated hemoglobin levels and body weight, along with greater overall improvements in the lipid profile compared to semaglutide in patients with T2DM, elevating incretin therapeutic agents to a new level (112)
PubMed Central , JAMA , vol
In the second part of this clinical trial, researchers led by Sanyal will follow nearly 1,200 participants from 37 countries for up to five years to gather data on semaglutides impact on long-term liver complications
The findings suggest that GLP-1 receptor expression may be a key factor in determining the safety of semaglutide for patients with NENs
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