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Ensure adequate calcium and vitamin D intake
Age represents one clear response modifier, with some evidence suggesting greater absolute improvements in older patients with more pronounced baseline deficits in matrix density and collagen content
Paraxanthine (1,7-dimethylxanthine, PXN) is the main metabolite of CAF, accounting for 7072% of ingested CAF and 85% of the methylxanthine metabolic by-products (Stavric 1988)
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