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Previous animal and human studies suggest an ultrahigh dose methylcobalamin, a form of vitamin B12, injection is safe, tolerable, and effective in slowing down functional decline in the early stages of ALS
The available human data is smaller than for older peptides because MOTS-c is a relatively recent therapeutic
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However, the exact role of GST enzymes in the mechanism of ISR is still far from elucidated because transgenic plants overexpressing or suppressing the symbiont-inducible GSTs have been rarely studied (Kao et al., 2016)
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