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Vitamin B12 Injections are better than oral vitamin B12 supplements, because they enter the bloodstream directly without having to pass through the digestive system, which makes them a suitable option for those who suffer from health problems in the digestive system

FDAs 2023 Category 2 placement cited immunogenicity risk for certain routes of administration, peptide-related impurities, complexities in active pharmaceutical ingredient (API) characterization, and limited safety information for the proposed routes

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