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Standard practice includes: Baseline thyroid function tests (TSH and free T4) before initiating GLP-1 therapy Repeat testing at 812 weeks after starting treatment or after dose escalation Regular monitoring every 36 months during active weight loss Return to annual monitoring once weight is stable and thyroid function remains consistent Adjustments to levothyroxine dosing may be necessary as weight changes

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Both remain investigational compounds available only through clinical trials or research chemical suppliers

However, these observational studies have inherent limitations, including potential residual confounding (as some registries lack complete data on important cancer risk factors like smoking), selection bias, and the challenge of detecting rare events