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If your goal is maximum total weight loss and you have significant weight to lose (30+ pounds), GLP-1 agonists deliver the largest magnitude of change
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[42] pooled 31 long-duration RCTs (84,713 participants) of GLP-1 RAs in diabetes and obesity, populations again largely free of significant psychiatric comorbidity, and found no increase in depression, anxiety, or suicidality, providing robust evidence for psychiatric safety in large, controlled settings
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