Notably, the highest dose tested (54 mg) showed increased gastrointestinal event frequency compared to lower doses, suggesting a dose-relationship for this effect category
Long-Term Weight Loss & Maintenance with Semaglutide in Obesity (2022 Review of STEP Trials) consolidates findings across multiple STEP trials (1, 3, 4, 8), showing 14.917.4% mean weight loss over 68 weeks, improved cardiometabolic markers, and better quality-of-life outcomes
Even though some micronutrients, such as Ca, Mg, Fe, folic acid, and Vit D, have been shown by some researchers to exert a protective effect in sleep [14, 15, 33, 34] while K reportedly has the opposite effect [35], our study did not find any associations between these micronutrients and insomnia
Greater endurance enhanced ability to maintain effort over time due to more efficient oxygen utilization