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The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis
Notably, this sequence contains non-proteinogenic residues including alpha-aminoisobutyric acid (Aib) and D-amino acids (D-2-naphthylalanine and D-phenylalanine), which are deliberately incorporated to enhance metabolic stability and receptor-binding selectivity
MT-II vertoont niet-selectieve agonistische activiteit op vier van de vijf melanocortinereceptoren
These findings establish ferroptosis as a key mechanism in myoglobin-induced nephrotoxicity ( Figure 5 )
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