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The paramagnetic probe, S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioate (MTSL), was used to label the cysteine residue 46 of p53 TAD 67 , where 300 M MTSL-labeled p53 TAD was added to 150 M 15 N-labeled FOXO4 FHD
( c ) Kaplan Meier Overall Survival (OS) of patients split as in ( b ), with Log rank test and hazard ratio analyses reported
The active GSH rapidly oxidizes into the inactive GSSG
Acetaldehyde is also responsible for the development of liver disease and is a known neurotoxin that can contribute to cognitive decline with chronic binge drinking
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