Average weight loss hides how many people actually hit meaningful thresholds, so the trials also report the share of participants reaching 5%, 10%, 15%, and 20% body-weight reductions
Discussion of lifestyle factors is equally important: dietary patterns, caloric intake, physical activity levels, sleep quality, and stress management all significantly influence metabolic outcomes and may explain apparent treatment resistance
To view or add a comment, sign in How to individualize renoprotective therapy in obese patients with chronic kidney disease: a commentary by the Diabesity Working Group of the ERA Open Access Nephrology Dialysis Transplantation, Volume 40, Issue 10, October 2025, Pages 19771988, Published: 13 May 2025 The interrelated pandemics of obesity and type 2 diabetes mellitus (T2DM) are fuelling an increase in the prevalence of chronic kidney disease (CKD), which amplifies the risk of cardiovascular events and may progress to end-stage kidney disease (ESKD)
More research is needed to determine whether similar effects occur with other weight-loss medications, including newer drugs such as those used in Zepbound