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Using GLP-2R WT and KO mice, we demonstrated that McBs protective effects were entirely abolished in GLP-2R KO mice, and completely independent of hormone secretion, underscoring the necessity of intact GLP-2R signaling for McB-mediated intestinal resilience
Production of metabolites from amino acids, however, could play an important role in GLP-1 secretion from the colon, as the microbiota can ferment nutrients reaching the distal intestine (mostly colon) and produce metabolites, which may stimulate GLP-1 and PYY secretion [36,37,38]
It may help with conditions like leaky gut, IBS, or bloating, especially at 5-10 grams daily
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