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Bhmt deleted mice were observed to have significantly high hepatic triglycerides and later developed hepatic tumors (Teng et al., 2011), indicating that reduced BHMT activity may increase the susceptibility to fatty liver and hepatocellular carcinoma

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The debate is more reasonable than it looks: the 28 days is not printed on the label, it is the default beyond-use date USP General Chapter 797 assigns to any opened multi-dose vial