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354 Combating strategies Overcoming microbiome-mediated therapeutic resistance necessitates a multifaceted approach integrating microbial profiling, precision modulation, and hostmicrobiotaimmune interplay (Fig

Further validation by western blot revealed that the level of JAK2 and STAT4 in the shGSTM3 were enhanced significantly than that in the shNC, and vice versa in the GSTM3-OE (Figure 8E)

Next, the many challenges associated with drug design are discussed and we urge additional research attention to neurotrophins given their demonstrated ability to address several of the pathologies that characterize AD