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Its responsible for neutralizing harmful free radicals, supporting liver detoxification, and strengthening the immune system

4.3 Activators of the system Xc-/GSH/GPX4 axis As a central antioxidant defense pathway in eukaryotic cells, the System Xc-/GSH/GPX4 axis performs a fundamental role in maintaining cellular redox homeostasis and averting ferroptosis (131)

For example, clinical trials evaluating PDE1 and PDE10A inhibitors have yielded inconsistent outcomes, with some compounds showing improvements in cognitive or negative symptoms while others failed to achieve primary outcomes (Table 2)

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