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KLOW and its components are not approved medicines
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[ 3 H] GSSG uptake assay in immunopurified ER SLC33A1 knockout HEK293T or Slc33a1 knockout KPK cells expressing EMC3-mScarlet-3xHA (ER-tag) complemented with a vector control or SLC33A1 cDNA were treated with 1 mM BSO for 48 hours prior for ER isolation
Because copper itself has a narrow physiological range, protocols involving repeated or high-frequency application in animal models often include copper-load monitoring alongside the primary remodeling endpoints, to rule out confounding from excess trace-mineral exposure rather than peptide-specific signaling
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