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Results Autocrine-based selection of a novel GLP-1R agonist To identify potential G-protein-biased ligands for the GLP-1R we expressed a peptide library at the cell surface of a reporter cell line co-expressing the GLP-1R and the green fluorescent protein (GFP) reporter gene under the control of a CRE promoter (HEK293-GLP-1R-GFP) to screen for peptides that induce GLP-1R-mediated cAMP production

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