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"Today's announcement builds upon our historic Most Favored Nations drug pricing deals' goal of democratizing access to weight-loss medication, which has been out of reach for so many in need," CMS Administrator Mehmet Oz, MD, said in a statement in December 2025

Researchers became interested in the fragment because it appeared to retain some of the signaling activity of the parent molecule while being far smaller and easier to work with

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While treatments like retinoids and chemical peels have their place, they often come with potential side effects, including redness, peeling, and sun sensitivity