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Most of this can be explained by the link between weight and risk described in Part 1, but mortality improvements observed in clinical trials that cannot be predicted from weight-loss alone are also allowed for
Additionally, YeaW/X, a system homologous to CntA/B, can also metabolize carnitine, choline, -butyrobetaine, and betaine to generate TMA
& Singh, A
With clinically meaningful weight loss and cardiovascular outcomes in patients with type 2 diabetes, GLP-1RAs were further assessed in patients with overweight or obesity without type 2 diabetes in the 2021 STEP-1 trial and 2022 SURMOUNT-1 trial
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