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The panel also voted 8-6 to place another form known as acetate on the list
In a perivascular adipose tissue inflammation model, macrophages deficient in SIRT3 exhibited a metabolic switch from oxidative phosphorylation to glycolysis, resulting in lactate accumulation and subsequent promotion of NLRP3 inflammasome activation and IL-1 secretion (133).In summary, the regulation of the NLRP3 inflammasome by lactate is not unidirectional
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