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In December 2024, the companies entered into an exclusive global license agreement for Hansoh Pharms HS-10535 (now MK-4082), which gave Merck an exclusive global license to develop, manufacture, and commercialize the drug in a $2.0-billion deal ($112 million upfront and milestone payments of up to $1.9 billion)

For patients with higher risk factors, such as significant stomach symptoms or known delayed digestion, simple precautions can reduce risk

After significant weight loss, some patients may qualify for procedures such as panniculectomy or body contouring to remove excess skin