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In the CNS, GLP-1Rs are expressed by neurons in the hippocampus, which is known to be a cognition-related brain region, and have been observed in neocortical pyramidal neurons (McClean and Holscher, 2014

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The case study reveals that following the administration of semaglutide, the patient exhibited a 20-point reduction in his Alcohol Use Disorders Identification Test (AUDIT) score and a marked reduction in alcohol use, including binge-drinking episodes