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The current therapeutic landscape reflects this new precision
meningitidis , the HrpA/HrpB TPS was implicated in diverse functions, including competition between meningococci as a toxin-antitoxin fratricide system, biofilm formation, adherence to epithelial cells, intracellular survival, vacuolar escape, interaction with dynein, and modulation of apoptosis/pyroptosis (Schmitter et al., 2007
Wu K-J, Grandori C, Amacker M, Simon-Vermot N, Polack A, Lingner J, et al
It activates the HGF/Met signaling pathwaypromoting synaptogenesis and dendritic spine formationat picomolar concentrations that exceed brain-derived neurotrophic factor and other nootropic compounds by several orders of magnitude
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