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Evidence-based stress reduction techniques include regular physical activity (which you should already be doing for muscle preservation), adequate sleep (see next section), mindfulness or meditation practices even for just 10 minutes daily, limiting news and social media consumption, setting boundaries around work hours, and addressing relationship or financial stressors directly rather than avoiding them
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Four weeks is often still during dose escalation (typically 2.5 mg), and your body may need the full 812 week timeline to reach therapeutic doses where appetite suppression becomes pronounced
Those with pre-existing chronic liver disease warrant closer surveillance, though semaglutide is not contraindicated in compensated liver disease
