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The result can be an order-of-magnitude increase in half-life
RA patients commonly present with elevated iron metabolism indicators like serum iron and ferritin, and the concentration of iron is positively correlated with the severity of joint inflammation ( 4.2 Lipid peroxidation and oxidative stress in RA Oxidative stress as a major pathogenic hallmark of RA promotes the local microenvironment at the RA lesion sites, enhances abnormal synoviocytes proliferation, and exacerbates inflammatory infiltration ( In RA, excessive ROS accumulation and sustained inflammatory activation promote synovial, vascular, and joint damage
PMID 27089158
17: Sikiric P, Boban Blagaic A, Krezic I, Zizek H, Kalogjera L, Smoday IM, Vukovic V, Oroz K, Chiddenton HM, Buric S, Antunovic M, Gojkovic S, Strbe S, Skocic M, Sikiric S, Milavic M, Beketic Oreskovic L, Kokot A, Koprivanac A, Dobric I, Sever M, Staresinic M, Batelja Vuletic L, Skrtic A, Seiwerth S
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