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Safety Profile and Tolerability Concerns Gastrointestinal Adverse Effects While GLP-1RAs are effective in managing obesity, their use is associated with gastrointestinal side effects and rare but serious adverse events [42] [43] [44]

In research models, it has been shown to enhance fat oxidation , reduce adiposity , and improve insulin sensitivity

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When exercise was added, these negative effects were largely prevented: exercised rats had higher total bone mineral content, lean mass, and serum IGF-1, and their bone mechanical strength was maintained despite reduced energy availability